An IV bolus delivers 300 mg into a system with Vd of 25 L. What is the initial concentration C0?

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Multiple Choice

An IV bolus delivers 300 mg into a system with Vd of 25 L. What is the initial concentration C0?

Explanation:
For an IV bolus, the drug is instantly distributed within the volume of distribution, so the initial concentration equals the dose divided by Vd. C0 = Dose / Vd. Plugging in the values: C0 = 300 mg / 25 L = 12 mg/L. Thus the initial concentration is 12 mg/L. The other numbers would require a different Vd or dose, so they don’t fit the given values.

For an IV bolus, the drug is instantly distributed within the volume of distribution, so the initial concentration equals the dose divided by Vd. C0 = Dose / Vd.

Plugging in the values: C0 = 300 mg / 25 L = 12 mg/L.

Thus the initial concentration is 12 mg/L. The other numbers would require a different Vd or dose, so they don’t fit the given values.

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