How do you estimate clearance from AUC after IV dosing?

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Multiple Choice

How do you estimate clearance from AUC after IV dosing?

Explanation:
The key idea is that, after an IV dose with linear pharmacokinetics, exposure (AUC) is proportional to the dose and inversely proportional to clearance: AUC_iv = Dose / CL. To estimate clearance from the observed AUC, solve for CL: CL = Dose / AUC_iv. The units line up nicely (dose in mg, AUC in mg·h/L gives CL in L/h). For example, a 100 mg dose with an AUC_iv of 5 mg·h/L gives CL = 100 / 5 = 20 L/h. (Dose = AUC_iv × CL is the same relationship, just rearranged.)

The key idea is that, after an IV dose with linear pharmacokinetics, exposure (AUC) is proportional to the dose and inversely proportional to clearance: AUC_iv = Dose / CL. To estimate clearance from the observed AUC, solve for CL: CL = Dose / AUC_iv. The units line up nicely (dose in mg, AUC in mg·h/L gives CL in L/h). For example, a 100 mg dose with an AUC_iv of 5 mg·h/L gives CL = 100 / 5 = 20 L/h. (Dose = AUC_iv × CL is the same relationship, just rearranged.)

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