If a drug is given IV with Dose = 200 mg and AUC_iv = 40 mg·h/L, what is the clearance (CL)?

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Multiple Choice

If a drug is given IV with Dose = 200 mg and AUC_iv = 40 mg·h/L, what is the clearance (CL)?

Explanation:
Clearance for IV dosing is found from the relationship CL = Dose / AUC. Since the drug is given intravenously, bioavailability is 1, so no absorption term is involved. With a dose of 200 mg and an AUC of 40 mg·h/L, the calculation is 200 mg ÷ 40 mg·h/L = 5 L/h. The units cancel correctly to L/h, so the clearance is 5 L/h.

Clearance for IV dosing is found from the relationship CL = Dose / AUC. Since the drug is given intravenously, bioavailability is 1, so no absorption term is involved. With a dose of 200 mg and an AUC of 40 mg·h/L, the calculation is 200 mg ÷ 40 mg·h/L = 5 L/h. The units cancel correctly to L/h, so the clearance is 5 L/h.

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