If a drug is given orally with F less than 1, how does the oral AUC compare with the IV AUC when equal doses are used?

Unlock all questions

This demo includes only 20 questions. Upgrade to access hundreds of questions, flashcards, exam simulations, and disable ads.

Full question bankExam simulationsFlashcards

From $24.99Unlock all

Prepare thoroughly for the MDC Pharmacokinetics Exam with our detailed guidance. Utilize flashcards and multiple-choice questions, complete with hints and explanations, to excel in your test!

Multiple Choice

If a drug is given orally with F less than 1, how does the oral AUC compare with the IV AUC when equal doses are used?

When a drug is given orally, only a fraction F of the dose reaches systemic circulation. The AUC for an extravascular dose is proportional to F × Dose divided by clearance (AUC = F × Dose / Cl). For an IV dose, F is 1, so AUC_IV = Dose / Cl. With equal doses, AUC_oral = F × Dose / Cl, which is smaller than AUC_IV when F < 1. Therefore, the oral AUC is less than the IV AUC. This reflects incomplete bioavailability due to absorption and first-pass effects.

If a drug is given orally with F less than 1, how does the oral AUC compare with the IV AUC when equal doses are used?

Prepare thoroughly for the MDC Pharmacokinetics Exam with our detailed guidance. Utilize flashcards and multiple-choice questions, complete with hints and explanations, to excel in your test!

If a drug is given orally with F less than 1, how does the oral AUC compare with the IV AUC when equal doses are used?

Get the latest from Examzify