IV bolus: If Dose is doubled and Vd constant, C0 will:

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Multiple Choice

IV bolus: If Dose is doubled and Vd constant, C0 will:

Explanation:
In IV bolus, the initial plasma concentration C0 is equal to the dose divided by the volume of distribution (C0 = D/Vd). This reflects how much drug is in the body at time zero relative to the volume into which it is dispersed. If you double the dose while keeping Vd constant, the amount of drug in the body doubles but the distribution volume stays the same, so the concentration in the plasma also doubles. Elimination hasn’t had time to lower the concentration yet, so C0 directly mirrors the dose. So the initial concentration will double.

In IV bolus, the initial plasma concentration C0 is equal to the dose divided by the volume of distribution (C0 = D/Vd). This reflects how much drug is in the body at time zero relative to the volume into which it is dispersed. If you double the dose while keeping Vd constant, the amount of drug in the body doubles but the distribution volume stays the same, so the concentration in the plasma also doubles. Elimination hasn’t had time to lower the concentration yet, so C0 directly mirrors the dose.

So the initial concentration will double.

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