Which dosage form is used for insertion into the rectum, vagina, or urethra?

• A. Enema
• B. Mouthwash
• C. Gargle
• D. Suppository

Answer: (D)

Suppositories are solid dosage forms molded to fit into body cavities such as the rectum, vagina, or urethra. They are designed to melt or dissolve at body temperature, releasing the drug either for local action at the site or for systemic absorption via the mucosa. The base—oleaginous like cocoa butter or water-soluble like PEG—controls how quickly the drug is released. The rectal route can provide local relief or, for some drugs, partial avoidance of first-pass metabolism, while vaginal and urethral forms are used for targeted local therapy or specific systemic needs. Enemas are liquids used rectally but are not intended for insertion into the vagina or urethra, and mouthwash or gargle are for the oral cavity. So the dosage form designed for insertion into rectum, vagina, or urethra is the suppository.