Which statement about k = CL / Vd is true?

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Multiple Choice

Which statement about k = CL / Vd is true?

Explanation:
Elimination rate constant k is determined by the ratio of clearance to volume of distribution: k = CL / Vd. This means k increases when clearance rises and/or decreases when the volume of distribution increases. If clearance doubles while the volume of distribution stays the same, k becomes twice as large. Conversely, if the volume of distribution doubles with clearance held constant, k becomes half as large. Since k depends on both CL and Vd, saying that k is independent of them is incorrect. Therefore, the statement that doubling clearance with the volume of distribution unchanged leads to a doubling of k is the correct one.

Elimination rate constant k is determined by the ratio of clearance to volume of distribution: k = CL / Vd. This means k increases when clearance rises and/or decreases when the volume of distribution increases. If clearance doubles while the volume of distribution stays the same, k becomes twice as large. Conversely, if the volume of distribution doubles with clearance held constant, k becomes half as large. Since k depends on both CL and Vd, saying that k is independent of them is incorrect. Therefore, the statement that doubling clearance with the volume of distribution unchanged leads to a doubling of k is the correct one.

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